2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113344
    16α-Hydroxyestrone 566-76-7 ≥98.0%
    16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease.
    16α-Hydroxyestrone
  • HY-119222
    GSK256073 862892-90-8 ≥98.0%
    GSK256073 is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia. GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
    GSK256073
  • HY-129630
    Tetrahydrocortisol 53-02-1 ≥99.0%
    Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity.
    Tetrahydrocortisol
  • HY-132205
    DS45500853 2735803-28-6 99.18%
    DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM).
    DS45500853
  • HY-13964A
    YIL781 hydrochloride 1640226-17-0 ≥99.0%
    YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively.
    YIL781 hydrochloride
  • HY-15398A
    5,6-trans-Vitamin D3 22350-41-0 99.81%
    5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
    5,6-trans-Vitamin D3
  • HY-15849A
    LP-533401 hydrochloride 1040526-12-2 98.02%
    LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
    LP-533401 hydrochloride
  • HY-159115
    ART26.12 2766800-24-0 99.57%
    ART26.12 is a potent, selective and orally active inhibitor of FABP5. ART26.12 can regulate lipid metabolism and activate cannabinoid receptors. ART26.12 has analgesic effects and can be used in the research of diseases such as peripheral neuropathy and psoriasis.
    ART26.12
  • HY-160186
    20-SOLA 98.76%
    20-SOLA is an orally active 20-HETE antagonist. 20-SOLA greatly ameliorates changes in blood pressure and renal injury associated with a Streptozotocin (STZ) (HY-13753)-diabetic mouse model. 20-SOLA facilitates the restoration of coronary collateral growth (CCG) after ischemic injury. 20-SOLA can be studied for research in cardiovascular diseases and diabetes.
    20-SOLA
  • HY-19528S
    SAH-d4 ≥99.0%
    SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM.
    SAH-d4
  • HY-P0203B
    β-CGRP (mouse) 99.77%
    β-CGRP (mouse) is a calcitonin gene-related peptide that induces vasodilation. β-CGRP (mouse) can be utilized in cardiovascular, pro-inflammatory, migraine and metabolic research.
    β-CGRP (mouse)
  • HY-P3016A
    Glutamate oxaloacetate aminotransferase, porcine heart 9000-97-9
    Glutamate oxaloacetate aminotransferase, porcine heart catalyzes the reversible reaction of L-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate.
    Glutamate oxaloacetate aminotransferase, porcine heart
  • HY-109854A
    (R)-Lisofylline 100324-81-0 ≥98.0%
    (R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.
    (R)-Lisofylline
  • HY-154021A
    5-Fluoromethylornithine dihydrochloride 124796-41-4
    5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride can be used in the study of gyrate atrophy of choroid and retina.
    5-Fluoromethylornithine dihydrochloride
  • HY-B0504S2
    Creatinine-d5 ≥99.0%
    Creatinine-d5 is the deuterium labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.
    Creatinine-d5
  • HY-N0830S5
    Palmitic acid-d3 75736-53-7 ≥98.0%
    Palmitic acid-d3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d3
  • HY-W004049
    3-Hydroxybenzoic acid 99-06-9 99.89%
    3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study.
    3-Hydroxybenzoic acid
  • HY-W012241
    Dodecanedioic acid 693-23-2 ≥98.0%
    Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic acid
  • HY-W016647
    For-Met-OH 4289-98-9 99.92%
    For-Met-OH is an endogenous metabolite.
    For-Met-OH
  • HY-W009371C
    D-Ribose 5-phosphate disodium dihydrate 207671-46-3 ≥99.0%
    D-Ribose 5-phosphate disodium dihydrate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.
    D-Ribose 5-phosphate disodium dihydrate
Cat. No. Product Name / Synonyms Application Reactivity